Sex differences in neurological research
There are distinct neurobiological differences between the male and female brain, evident in both healthy individuals and those affected by neurodegenerative diseases.
Historically, in vitro model development has been disproportionately focused on male biology, reflecting a bias that has shaped research for decades. This, coupled with the lack of readily available female models, has hindered researchers' ability to study critical sex differences in drug responses and cellular functions, leaving considerable gaps in our understanding of neurodegenerative diseases.
Join Antonella Santuccione Chadha, Melanie Einsiedler from the Women’s Brain Foundation, and Rebecca Northeast from 911±¬ÁÏÍø for an insightful webinar. They will explore the importance of incorporating female representation in in vitro models and discuss how the latest cell programming technology is providing microglia with a female donor background to advance neurological research.
Topics to be covered:
- Introduction to the Women's Brain Foundation and the challenges they aim to solve
- Practical strategies for integrating sex as a biological variable in the design of in vitro models for neurological disorders
- How 911±¬ÁÏÍø’s deterministically programmed human iPSC-derived female microglia provide a rapid, functional solution for addressing sex differences in neurodegeneration and drug discovery.